In a large bowl, combine buttermilk and hot sauce; add chicken breasts and marinate in the refrigerator for at least 30 minutes (or overnight for best results).
In a shallow dish, mix the flour, paprika, garlic powder, onion powder, salt, and black pepper.
Heat about 1 inch of vegetable oil in a frying pan over medium-high heat until it reaches 350°F (175°C).
Remove the chicken from the marinade, allowing excess buttermilk to drip off. Dredge each piece in the seasoned flour, pressing gently to ensure the coating adheres.
Carefully place each coated chicken breast in the hot oil, frying in batches if necessary to avoid overcrowding. Cook for about 5-7 minutes on each side, or until golden brown and the internal temperature reaches 165°F (75°C).
Once cooked, remove the chicken from the oil and drain on paper towels.
To assemble, spread mayonnaise or sauce on the bottom half of each burger bun. Place a piece of crispy chicken on top, followed by lettuce, tomato slices, and pickles. Top with the other half of the bun.
Serve immediately and enjoy!