Preheat the oven to 425°F (220°C).
Line a baking sheet with parchment paper for easy cleanup.
In a mixing bowl, combine the broccoli florets, bell peppers, cherry tomatoes, zucchini, and red onion.
Drizzle the olive oil over the vegetables and sprinkle garlic powder, oregano, paprika, salt, and pepper. Toss well to coat evenly.
Spread the seasoned vegetables in a single layer on the prepared baking sheet.
Roast in the preheated oven for 20-25 minutes, or until the vegetables are tender and slightly browned, stirring halfway through for even cooking.
Remove from the oven and let cool for a few minutes before serving.