Preheat your oven to 350°F (175°C). Lightly grease your loaf pan or line it with parchment paper.
In a large mixing bowl, combine the ground beef, ground turkey, gluten-free breadcrumbs, eggs, chopped onion, chopped bell pepper, ketchup, Worcestershire sauce, garlic powder, Italian herbs, salt, and pepper.
Mix all the ingredients together until well incorporated, being careful not to overmix.
Transfer the meat mixture into the prepared loaf pan and shape it into a loaf.
Spread a thin layer of ketchup on top of the meatloaf for added flavor.
Place the loaf pan on a baking sheet to catch any drippings and bake in the preheated oven for 60 minutes, or until the internal temperature reaches 160°F (70°C).
Remove from the oven and let it rest for about 10 minutes before slicing.