In a mixing bowl, combine the ground beef with garlic powder, onion powder, salt, and black pepper. Mix until well blended, but do not overwork the meat.
Shape the meat into 4 equal-sized burger patties.
Heat a grill pan or skillet over medium-high heat. Cook the patties for about 3-4 minutes on each side or until cooked through to your desired doneness.
In the last minute of cooking, place the shredded cheddar cheese on top of each patty. Cover the pan with a lid to help the cheese melt.
While the burgers are cooking, warm the tortillas in a separate skillet over low heat for about 30 seconds on each side.
When the patties are cooked, remove them from the heat and start assembling your tortilla burgers. Spread mayonnaise on each tortilla.
Place a cheesy burger patty in the center of each tortilla, then top with shredded lettuce, diced tomato, sliced onion, and avocado. Optionally drizzle with taco sauce.
Fold the sides of the tortilla over the filling and then roll it up tightly from the bottom to enclose the burger and toppings.
Serve immediately, and enjoy your delicious tortilla burgers!